Is Generic Ibuprofen The Same As Advil – Prize-packed pills promise instant relief or claim to work for certain types of pain. But what is the scientific evidence that they are better than their lower-priced competitors?
For most people, the pain is unpleasant. So when menstrual pain started to attack, I looked for painkillers. I passed the branded ones on the supermarket shelves, their colorful packaging, their eye-catching labels. Instead, I bought a package of what looked like generic painkillers. To choose the pain I want, I look for the active ingredients listed on the box, not the promises.
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But it is not surprising that there is confusion. The variety of over-the-counter medications is huge and can be overwhelming, especially if you have a headache and are feeling vulnerable. Products that make loud noises, that claim to take away all your pain, are tempting.
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There are valid reasons why leading drugs cost more. The pharmaceutical company that produces it will carry out millions of pounds worth of research and initial drug trials that are vital to the safety of the product. Cheaper generic drugs are made by companies that create cheaper versions when the patent held by the brand leader has expired. So, are expensive drugs more effective than cheaper generic drugs?
The BBC2 series Believe Me is a doctor who turns to science to try to find out. Different types of painkillers, all containing ibuprofen, were selected, and scientists from the pharmaceutical laboratory at University College London carried out a series of experiments. The first compared two popular products containing ibuprofen at higher prices compared to three generic products. First, they check whether the product contains as much ibuprofen as stated on the box. In the UK, all licensed medicines are strictly controlled by the Medicines and Healthcare products Regulatory Agency (MHRA); with confidence, each product contains the right amount of ibuprofen.
The second test tries to find out how quickly the drug is released from the tablet – the dissolution test – by simulating how quickly ibuprofen changes into a form that can enter our blood. The results are very clear. When the tablet is added to the solution, most of the different products begin to release the medication immediately. The British Pharmacopoeia guidelines state that to be marketable, a minimum percentage of the active ingredient must be released within a specified time period. For ibuprofen tablets, this means 75% of the drug must dissolve within 45 minutes. Different products release medication at different rates, but all must meet these minimum limits.
Simon Gaisford, head of pharmaceuticals at UCL, explains: “If I were a company and wanted to develop a generic product, I would have to demonstrate to the MHRA that my product was bioequivalent to the brand leader.” This means that the new generic product must reach the bloodstream at the same time as the brand leader. In this case, all products tested reached the bloodstream, regardless of price. The results showed differences in release rates, but the generic product and the generic brand released the product. most of the ibuprofen within 45 minutes. There are no significant differences between the various products of the manufacturer.
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Therefore, it seems pointless to pay for expensive pills containing the active painkiller you want to use – cheaper pills are just as good.
But how many times have we heard products claim to “kill pain quickly”? Does paying more mean you’ll get rid of the pain faster? This claim is also governed by English law. According to MHRA guidelines, to justify the “rapid acting” claim, a drug must start working less than 30 minutes after oral administration. Two “rapid-acting” ibuprofen products – a branded and a generic – were tested, and more than 75% of both drugs were in solution within 20 minutes – compared with 45 minutes for the standard product. But again, although both act more quickly than the “standard” brands, there’s no point in paying more – the cheap, generic “show” products work just as quickly as the expensive brands. Ah.
Another marketing strategy is to define certain diseases. Some best-selling brands, such as Nurofen, combine ibuprofen in products for different types of pain. This can show you that there is something different in each box. In a statement to the BBC, Nurofen’s manufacturer, Reckitt Benckiser, said: “Dedicated pain relief products offer an easy way to relieve pain and consumer research shows that seven in 10 people say these packs help to decide on the best product for their needs.”
However, Ibuprofen does not target just one area of pain, but rather works on pain wherever it is located in the body. That’s right
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Ibuprofen products, regardless of price. The same goes for any painkillers you can buy without a prescription, such as paracetamol. In 2015, an Australian court found that Reckitt Benckiser had misled the public by marketing four Nurofen products saying they targeted specific types of pain – back pain, menstrual pain and headaches – when in fact they were the same. . The company states that all Nurofen products with the same active ingredient, package size, shape and formulation have the same manufacturer’s retail price. But this year, the Advertising Standards Authority commissioned Nurofen to create one of the brand’s ads “specifically for pain”.
But Nurofen isn’t the only product marketing “pain-specific” ibuprofen. Ultimately, the best protection against overpayment is the knowledge that, under UK law, consumers are protected and can safely purchase the cheapest brand on offer. However, if you want to spend your day pain-free, and don’t have the patience to wait, you can pay more for the white version. But a generic quick form will be just as effective as an expensive form in its pretty packaging. Two crossed lines that form an ‘X’ This shows how to close the interaction, or remove the notification.
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If you’ve ever been tempted to buy Wal-Itin half the price instead of Claritin, you’re not alone. Cheap store brands are tempting, but we all wonder: Are they really any good? How is that possible, when Advil is 50% superior to CVS brand ibuprofen?
The fact is this: Generic drugs are no less than branded drugs. It’s just more expensive – so don’t worry about it being cheap. Both generic and store brand medications have been rigorously tested, are well formulated, and are as effective as their brand names.
The low price actually has a simple explanation. Large companies provide marketing, advertising, and much of the drug development. Generic drug manufacturers don’t charge that much – and they pass the savings on to you.
This doesn’t just apply to drugs you buy on the street. If your doctor prescribes a brand-name drug, you can ask for a generic drug if it is available, and it will work just as well.
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Generic drugs, both over-the-counter and prescription drugs, are strictly regulated by the Food and Drug Administration (FDA) generic drug regulations.
Ultimately, the performance differences between brand name and generic drugs are similar to the differences between brands. “There will always be a small, but not clinically significant, level of natural variation – such as one level of a brand-name drug compared to a next-generation brand-name product,” the FDA said.
These distinctions are often pointless, except for one thing: a small class of drugs with a so-called ‘Narrow Therapeutic Index’, or very small window of effectiveness. “NTI medications include anticonvulsants to treat seizures, blood thinners such as warfarin, antiarrhythmics to control irregular heartbeats, and medications to help prevent rejection of transplanted organs,” explains Consumer Reports. In these limited circumstances, even small differences are unacceptable, both between brands and between brands in general.
But for other people, generic pills may look different or taste strange, but their efficacy is not medically relevant. The taste, color and other inactive ingredients of generic drugs are not necessarily the same as the branded version, but in terms of how the drug works in your body, they are the same.
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In a CDC study in rural Alabama, researchers found that people refused to buy generic drugs, even when they were short on cash. When asked why, participants said they thought generics “would require higher doses” and “other side effects.” They also said they view generics as “not ‘real’ drugs,” and as “small but not” convenient.
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