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Are Celiac And Lupus Related
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National Lupus Awareness Month 2023
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The link between celiac disease and systemic lupus erythematosus in children is a model for the development of autoimmune diseases, from what we inherit to what we eat.
Vasile Valeriu Lupu Vasile Valeriu Lupu Scilit Preprints.org Google Scholar 1, Elena Jechel Elena Jechel Scilit Preprints.org Google Scholar 1, Cristina Maria Mihai Cristina Maria Mihai Scilit Preprints.org Google Scholar 2, Elena Cristina Mitrofan Elena Cristina Mitrofan Scilit Preprints. org Google Scholar 3, Ancuta Lupu Ancuta Lupu Scilit Preprints.org Google Scholar 1, * , Iuliana Magdalena Starcea Iuliana Magdalena Starcea Scilit Preprints.org Google Scholar 1, Silvia Fotea Silvia Fotea Scilit Preprints.org Google Scholar 4, * , Adriana Motea Scholar 4, * , Adriana Motea Mocanu Scilit Preprints.org Google Scholar 1, Dragos Catalin Ghica Dragos Catalina Ghica Scilit Preprints.org Google Scholar 1, Costica Mitrofan Costica Mitrofan Scilit Preprints.org Google Scholar 1, Dragos Munteanu Dragos Munteanu Scilit Preprints.org Google Scholar 1, Delia Saoire Delia Lidia Salaru Scilit Preprints.org Google Scholar 5, Ionela Daniela Morariu Ionela Daniela Morariu Scilit Preprints.org Google Scholar 5 and Ileana Ioniuc Ileana Ioniuc Scilit Preprints.org Google Scholar 1
Celiac Disease What It Is, What It Isn’t Knowing The Difference
Received: 12 May 2023 / Revised: 22 May 2023 / Accepted: 26 May 2023 / Published: 29 May 2023
(This article belongs to the special issue “Updates in Nutritional Therapy and Therapeutic Approaches to Celiac Disease”).
Celiac disease (CD) and systemic lupus erythematosus (SLE) are two diseases that have been intensively studied in all age groups, with increasing incidence worldwide, possibly due to increased awareness of these diseases and their accurate diagnosis, as well as new research. and innovative technologies appearing in medicine. The first is a controlled condition, occurring in about 1% of the general population as a reaction to environmental irritants, affecting people with a genetic predisposition, causing gluten intolerance, gastrointestinal and extra-digestive symptoms from subclinical stages in sharp detail. On the other hand, lupus is an autoimmune disease with chameleon-like symptoms, which occurs mainly in women, leaving its clinical mark on most organs – from the skin, eyes and kidneys to the cardiovascular , pulmonary, neurological, osteoarticular and other organs. and hematology systems. Current research is focusing on the correlation between celiac disease and other autoimmune pathologies, such as autoimmune thyroiditis (Hashimoto’s and Graves-Basedow), type I diabetes, and systemic lupus erythematosus. The purpose of this review is to provide a summary of the literature regarding the current relationship between celiac disease and lupus by analyzing the most recent studies published on PubMed.
Celiac disease, also known as gluten-sensitive enteropathy, is characterized by a disorder of the internal environment associated with histological changes in the small intestine, the most important of which is subtotal villous atrophy with crypt hyperplasia. Clinically, it manifests itself with a wide range of symptoms: from gastrointestinal disorders (diarrhea, bloating, weight loss, abdominal pain) to extraintestinal symptoms (iron deficiency anemia, delayed puberty, oral ulcers), concentrated in different levels of severity. malabsorption [1, 2]. At an estimated prevalence of 1:100, serological screening is performed by titration of tissue transglutaminase antibodies (TGA) considered positive at values greater than twice the normal limit, doubled by genetic testing for human leukocyte antigen (HLA)-DQ2 or HLA-. Distribution of DQ8 and immunoglobulin A. Regarding duodenal biopsy, the European Society of Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) recommends its use in cases where TGA-IgA is positive <10 times above the upper limit of normal values, and the possibility exists. of retention if TGA -IgA is more than 10 × the upper limit of normal values in association with endomysial antibody positivity in two blood samples. However, there are authors in the literature who are able to confirm the diagnosis using digestive endoscopy with biopsy in patients with synonymous screening results but with strong clinical suspicion after a period of time when the child was normal (containing gluten). diet [2], 3, 4 , 5].
An Autoimmune Like Antibody Response Is Linked With Severe Covid 19
Juvenile systemic lupus erythematosus is a multisystem autoimmune/inflammatory disease that usually begins before the age of 18 (in about 15-25% of all SLE patients), where, unlike the adult form, it manifests increased activity depending on factors such as gender. , ethnicity. and early age, which causes significant damage and requires aggressive therapy. Incidence ranges from 0.36 to 2.5 per 100,000 children, with a prevalence of 1.89-34.1 per 100,000, peak incidence at age 12.6 years, and the pathophysiological basis points to the involvement of a genetic component, with > U 7% of patients develop the disease. disease resulting from single mutations, and 5-year survival improved from 30-40% in the 1950s to >90% in the 1980s. Diagnosis and therapy can be complex and are influenced by lesion polymorphism (more aggressive in terms of renal, hematologic, and neuropsychiatric components), the need for individual treatment, and drug interactions or comorbidities that may, in some cases, threaten life. It is also worth mentioning atypical forms of lupus, which are characterized by the absence of autoantibodies, a severe course and a conservative prognosis, especially before the age of 5 years [6, 7, 8].
The CD-SLE correlation, which consists of two entities that are highly represented in pediatric practice, represents a crossroads in the study of autoimmune diseases, in terms of their onset, development, overlap and treatment. The purpose of this narrative review is to provide a summary of the literature on the association between celiac disease and lupus by analyzing the most recent studies published on PubMed.
Celiac disease is associated with several autoimmune diseases, thyroid disease and type 1 diabetes are defined as “associated conditions” or conditions that have an increased prevalence, but are not directly related to gluten consumption. Loci in the HLA region were found to be common to loci identified in SLE, and SLE is one of the three main autoimmune diseases that develop in first-degree relatives of patients with celiac disease. In addition, there is evidence of non-celiac autoimmune diseases in the spouses of patients with celiac disease, which contradicts the claim that genetics is the only predisposing factor, since partners do not share traits genetics with each other, but environmental factors the microbiome that influence the risk of developing autoimmunity [9, 10]. About 30% of all patients with celiac disease have one or more autoimmune diseases, but in the general population the prevalence is between 3% and 9.4%. Currently available evidence suggests that a shared genetic background is a major factor in the high prevalence of this association, but it is unclear whether extrinsic factors related to gluten such as age at first introduction, concurrent breastfeeding are involved , duration of gluten exposure and gluten-free. influence diet on the association between celiac disease and autoimmune diseases [9].
The importance of effective screening among SLE patients to detect CD was discussed in a study conducted in the Middle East, showing the results of increased prevalence among patients with autoimmune diseases, with a higher correlation in groups of patients with SLE. compared to control. Although the frequency of celiac disease markers is considered high in SLE patients, only anendomysial (EMA) and TGA showed significant differences compared to controls (data reported in the literature). The present study still found that 9.6% of the subjects tested positive for anti-gliadin antibodies (AGAG or AGAA), 3.5% for TGA, and 2.6% for EMA. The negative impact of lack of screening is the potential for misdiagnosis and treatment, which may lead to unnecessary immunosuppressant prescriptions associated with side effects [11].
Pdf] Possible Role Of Vitamin D In Celiac Disease Onset
In support of previously reported results, another study conducted at the Colentina Hospital and Institute of Maternal and Child Health in Bucharest, Romania, showed an increased prevalence of gluten-induced autoimmune diseases among patients with SLE compared to the general population in in common.
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